4-AMINO-3-FLUOROBENZOIC ACID
4-amino-3-fluorobenzoic acid
CAS: 455-87-8
Molecular Formula: C7H6FNO2
4-AMINO-3-FLUOROBENZOIC ACID - Names and Identifiers
| Name | 4-amino-3-fluorobenzoic acid |
| Synonyms | NSC 25758 4-AMINO-3-FLUOROBENZ 4-Amino-3-Fluorobenzoic 4-amino-3-fluoro-benzoicaci 4-AMINO-3-FLUOROBENZOIC ACID 3-FLUORO-4-AMINOBENZOIC ACID 4-amino-3-fluorobenzoic acid 4-AMINO-3-FLUOROBENZENECARBOXYLIC ACID |
| CAS | 455-87-8 |
| EINECS | 207-250-1 |
| InChI | InChI=1/C7H6FNO2/c8-5-3-4(7(10)11)1-2-6(5)9/h1-3H,9H2,(H,10,11) |
| InChIKey | JSKXHTHMCCDEGD-UHFFFAOYSA-N |
4-AMINO-3-FLUOROBENZOIC ACID - Physico-chemical Properties
| Molecular Formula | C7H6FNO2 |
| Molar Mass | 155.13 |
| Density | 1.430±0.06 g/cm3(Predicted) |
| Melting Point | 215-218°C |
| Boling Point | 320.8±27.0 °C(Predicted) |
| Solubility | Hot Water |
| Appearance | Fine Needles |
| Color | White to Light yellow to Light orange |
| pKa | 4.52±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD01660374 |
4-AMINO-3-FLUOROBENZOIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| RTECS | DG2525000 |
| Hazard Class | IRRITANT |
4-AMINO-3-FLUOROBENZOIC ACID - Introduction
4-amino-3-fluorobenzoic acid is an organic compound with the chemical formula C7H6FNO2. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: 4-amino-3-fluorobenzoic acid is a white crystalline solid.
-Melting point: about 212 ℃.
-Solubility: Soluble in water and some organic solvents at room temperature, such as ethanol and ether.
Use:
-Chemical synthesis: 4-amino-3-fluorobenzoic acid can be used as raw materials and intermediates in organic synthesis. It can be used to synthesize other organic compounds, such as drugs, pesticides, dyes, polymers, etc.
-Pharmaceutical application: This compound has certain biological activity, so it also has potential uses in pharmaceutical research and development.
Preparation Method:
The preparation method of 4-amino-3-fluorobenzoic acid is generally carried out by the following steps:
1.2-amino -1-fluorobenzene (2-aminofluorobenzene) reacts with sodium cyanate to generate 2-amino -1-fluorobenzonitrile (2-aminofluorobenzobenzene).
2. heating hydrolysis of 2-amino -1-fluorobenzonitrile to obtain 4-amino-3-fluorobenzoic acid.
Safety Information:
- 4-amino-3-fluorobenzoic acid is generally stable and relatively safe under normal use conditions.
-However, it may irritate the eyes, skin and respiratory tract, so direct contact should be avoided. Wear appropriate personal protective equipment such as gloves, goggles and respiratory protection.
-In the event of accidental contact or inhalation, immediately flush the affected area with clean water and seek medical assistance.
Nature:
-Appearance: 4-amino-3-fluorobenzoic acid is a white crystalline solid.
-Melting point: about 212 ℃.
-Solubility: Soluble in water and some organic solvents at room temperature, such as ethanol and ether.
Use:
-Chemical synthesis: 4-amino-3-fluorobenzoic acid can be used as raw materials and intermediates in organic synthesis. It can be used to synthesize other organic compounds, such as drugs, pesticides, dyes, polymers, etc.
-Pharmaceutical application: This compound has certain biological activity, so it also has potential uses in pharmaceutical research and development.
Preparation Method:
The preparation method of 4-amino-3-fluorobenzoic acid is generally carried out by the following steps:
1.2-amino -1-fluorobenzene (2-aminofluorobenzene) reacts with sodium cyanate to generate 2-amino -1-fluorobenzonitrile (2-aminofluorobenzobenzene).
2. heating hydrolysis of 2-amino -1-fluorobenzonitrile to obtain 4-amino-3-fluorobenzoic acid.
Safety Information:
- 4-amino-3-fluorobenzoic acid is generally stable and relatively safe under normal use conditions.
-However, it may irritate the eyes, skin and respiratory tract, so direct contact should be avoided. Wear appropriate personal protective equipment such as gloves, goggles and respiratory protection.
-In the event of accidental contact or inhalation, immediately flush the affected area with clean water and seek medical assistance.
Last Update：2024-04-09 20:49:11
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